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Protein language models: an embedding is not a mutation-effect score

BACKGROUND
1 SIGNALFIRST DETECTED 14 October 2026
Narrative synthesis pending — 1 signal collected.
How the story developed
14 Oct
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Other feeds and industry voices
7 Sept
Why protein-structure confidence scores cannot substitute for a biological assay

<!-- SC_OFF --><div class="md"><p>Disclosure: I run <a href="http://rewire.it">rewire.it</a>, where I published the article linked below.</p> <p>A FASTA sequence does not fully

OPINION · WHERE · ArtificialInteligenceOPEN STORY
27 Apr
Alignment Makes Models More Decisive Without Making Them More Truthful

<!-- SC_OFF --><div class="md"><p>&#x200b;</p> <p>## Abstract</p> <p>Post-training makes language models more decisive without necessarily making them more accurate — and we find

OPINION · HOW · ArtificialInteligenceOPEN STORY
14 Apr
Still a long way from predicting protein binding

<table> <tr><td> <a href="https://www.reddit.com/r/ChatGPT/comments/1skvcgt/still_a_long_way_from_predicting_protein_binding/"> <img alt="Still a long way from predicting protein

OPINION · WHAT · ChatGPTOPEN STORY
27 Mar
RYS Part 3: LLMs think in geometry, not language — new results across 4 models, including code and math

<table> <tr><td> <a href="https://www.reddit.com/r/LocalLLaMA/comments/1s59rct/rys_part_3_llms_think_in_geometry_not_language/"> <img alt="RYS Part 3: LLMs think in geometry, not

OPINION · WHAT · LocalLLaMAOPEN STORY
26 Apr
Stanford researchers fed a language model a DNA sequence and asked it to create a new virus. It wrote hundreds of them, and 16 worked. One used a protein that doesn't exist in any known organism on Earth.

<table> <tr><td> <a href="https://www.reddit.com/r/OpenAI/comments/1sw0vcf/stanford_researchers_fed_a_language_model_a_dna/"> <img alt="Stanford researchers fed a language model a

OPINION · WHAT · OpenAIOPEN STORY
2 Oct
10,000 Agents, a Millennium Prize, and Models That Learn to Lie: Noam Brown's Most Alarming Insights

<!-- SC_OFF --><div class="md"><p><strong>Noam Brown</strong> — OpenAI Research Scientist and co-creator of o1, Libratus, and Cicero — sat down with Dwarkesh Patel for a 1h 20m

OPINION · WHAT · ChatGPTOPEN STORY
21 Apr
New LLM Position Bias Benchmark: does an LLM keep the same judgment when you swap the answer order? Judge models compare two lightly edited versions of the same story twice, with the order swapped. The median model flips in 45% of decisive case pairs. GPT-5.4 is worst at 66%.

<table> <tr><td> <a href="https://www.reddit.com/r/singularity/comments/1srx4i1/new_llm_position_bias_benchmark_does_an_llm_keep/"> <img alt="New LLM Position Bias Benchmark: does

OPINION · WHEN · singularityOPEN STORY
24 Jul
Testing our Theory with a blind protein structure prediction workflow with a transparent alternative to neural network based approaches

<!-- SC_OFF --><div class="md"><p><strong>TL;DR:</strong> My partner and I developed a new mathematical approach to predicting how proteins fold into their three-dimensional

OPINION · WHERE · singularityOPEN STORY
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