Joint Discrete and SE(3) Diffusion for Protein Interface Design

arXiv:2609.28921v1 Announce Type: new Abstract: Protein modification requires navigating an immense sequence space, yet wet-lab validation remains low-throughput and costly.

arXiv:2605.04118v1 Announce Type: cross Abstract: Recent advances in de novo protein binder design have enabled increasing experimental validation, yet reported in silico metrics

arXiv:2609.30456v1 Announce Type: new Abstract: Reward maximization alignment methods for discrete diffusion models have primarily focused on steering the reverse process, either

arXiv:2609.19770v1 Announce Type: new Abstract: All-atom structure predictors model diverse molecular interactions, but using their learned structural priors for binder design

arXiv:2605.00354v1 Announce Type: cross Abstract: Many diffusion based molecule generation methods ignore the symbolic information of molecules and represent the atom and bond

arXiv:2605.15243v1 Announce Type: cross Abstract: When reliable target structures are unavailable at scale or phenotypes arise from dysregulated pathways, transcriptomic